Juvederm vs Restylane for Lips
Both brands make FDA-approved hyaluronic acid fillers for lips. Here is a plain-language look at what the FDA documents and manufacturers say about each.
5 to 7 minutes
the Find Lip Fillers editor
listed below
Filler Products
The Short Answer
Juvederm and Restylane are brands of hyaluronic acid (HA) filler, and each makes products approved by the FDA for lip augmentation. Both are gels injected into the lips, and both can be broken down with hyaluronidase, an enzyme that dissolves hyaluronic acid.
This guide compares what the FDA documents and manufacturers say about each product. It doesn't rank the brands. Which product suits you is a conversation to have with your provider.
Who Makes Them
Juvederm products are made by Allergan, part of AbbVie. Restylane products are made by Galderma. Each brand offers more than one product approved for the lips, and the products differ in how much hyaluronic acid they contain and what their approvals cover.
The Lip Products
Juvederm Ultra XC
Approved for injection into the lips and perioral area for lip augmentation in adults over 21. Contains 24 mg/mL hyaluronic acid and 0.3% lidocaine, a numbing agent. Its lip study followed people for 12 months.
Juvederm Volbella XC
Approved by the FDA in May 2016 for lip augmentation and for lines around the mouth in adults over 21. Contains 15 mg/mL hyaluronic acid and 0.3% lidocaine. Its study followed people through 12 months.
Restylane Silk
Approved by the FDA in June 2014 for lip augmentation and for lines around the mouth in adults over 21. Contains 20 mg/mL hyaluronic acid and 0.3% lidocaine. Its lip study followed people for 24 weeks. (The original Restylane was the first to have a lip indication added, in October 2011.)
Restylane Kysse
Approved by the FDA in 2020 for lip augmentation and for lines around the upper lip in adults 21 and older. Made with what Galderma calls XpresHAn Technology, and contains lidocaine. Galderma says it lasts up to 1 year.
Side by Side
How long a filler lasts depends on the filler material and where it is injected, so the study lengths above aren't a direct comparison of how long each product lasts.
Which Products Should You Ask About?
Answer 3 quick questions to see which lip products have FDA approval matching your goals, and get questions to bring to your consultation.
Questions to Ask Your Provider
- Which product would you use for my lips, and why that one?
- Which products do you stock and use most often?
- Does that product's FDA approval cover what I want, such as lines around the mouth?
- How long have results with that product lasted for your patients?
- If I've had a different brand before, would you switch, and why?
Frequently Asked Questions
Is Juvederm or Restylane better for lips?
This guide compares what the FDA documents and manufacturers say about each product, not which brand is better. Both brands have products approved for lip augmentation. Ask your provider which product they would use for your goals and why.
How long does Juvederm last in lips?
How long a filler lasts depends on the filler material and where it is injected. The lip studies for Juvederm Ultra XC and Juvederm Volbella XC followed people for 12 months. Ask your provider how long results have lasted for their patients.
How long does Restylane last in lips?
How long a filler lasts depends on the filler material and where it is injected. Galderma, the manufacturer, says Restylane Kysse lasts up to 1 year. The lip study for Restylane Silk followed people for 24 weeks.
Can Juvederm and Restylane be dissolved?
Yes. Both are hyaluronic acid fillers, and hyaluronidase is an enzyme that breaks down hyaluronic acid. Our dissolving guide covers what that appointment involves.
Which filler is right for first-time lip filler patients?
We found no published research comparing these products specifically for first-time patients. Ask your provider which product they would use, how much they would start with, and why.
Sources
- JUVÉDERM Ultra XC Directions for Use. AbbVie (manufacturer prescribing information).Supports: approved for injection into the lips and perioral area for lip augmentation in adults over 21; contains 0.3% lidocaine; 24 mg/mL hyaluronic acid; the lip study followed people for 12 months
- JUVÉDERM VOLBELLA XC: Summary of Safety and Effectiveness Data (P110033/S018). U.S. Food and Drug Administration.Supports: approved May 31, 2016 for lip augmentation and correction of perioral lines in adults over 21; Allergan is the applicant; 15 mg/mL hyaluronic acid with 0.3% lidocaine; follow-up through 12 months
- Restylane Silk Injectable Gel: Summary of Safety and Effectiveness Data (P040024/S072). U.S. Food and Drug Administration.Supports: approved June 13, 2014 for lip augmentation and perioral lines in patients over 21; 20 mg/mL hyaluronic acid with 0.3% lidocaine; lip study follow-up through 24 weeks; Restylane's lip indication was first approved October 11, 2011
- Galderma receives FDA approval for Restylane Kysse. Galderma (manufacturer announcement), May 6, 2020.Supports: Restylane Kysse is approved for lip augmentation and upper perioral lines in adults 21 and older; made with XpresHAn Technology; contains lidocaine; Galderma says it lasts up to 1 year
- Dermal Fillers (Soft Tissue Fillers). U.S. Food and Drug Administration.Supports: hyaluronic acid is one of the materials used in dermal fillers; how long the effect lasts depends on the filler material and where it is injected
- Jung H. Hyaluronidase: An overview of its properties, applications, and side effects. Arch Plast Surg. 2020;47(4):297–300. Peer-reviewed journal.Supports: hyaluronidase breaks down hyaluronic acid filler
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Editorial note
This guide is based on FDA approval documents and manufacturer information for each product. It does not constitute medical advice. Product availability, formulations, and clinical recommendations change over time — verify current information with your provider and consult the FDA database for the most up-to-date approval status.